Abstract: Objective To compare the therapeutic efficacy of transcatheter arterial chemoembolization （TACE） combined with either psychro-circulation percutaneous microwave coagulation therapy or radioactive ¹²⁵I particle implantation for treating large primary liver cancer （LPLC）. Methods A total of 46 patients with LPLC underwent TACE and psychro-circulation percutaneous microwave coagulation therapy using the ECO-100 system， while 20 patients underwent TACE and radioactive ¹²⁵I particle implantation.At 2 and 3 months after treatment， patients were analyzed by dynamic enhanced computed tomography scanning，and adverse reactions and complications were recorded. Results At 3 months after treatment，TACE combined with psychro-circulation percutaneous microwave coagulation therapy gave a local control rate of 82.61%，compared to 55.00% for TACE combined with radioactive ¹²⁵I particle implantation （P<0.05）. The two methods gave similar clinical control rates of 93.47% and 85.00%，respectively （P>0.05）.In addition，the two groups did not differ significantly in adverse reactions，and neither group showed serious complications. Conclusion TACE combined with either psychro-circulation percutaneous microwave coagulation therapy or radioactive ¹²⁵I particle implantation is effective for treating LPLC，and both methods cause similar adverse reactions.Of the two combination therapies，TACE combined with psychro-circulation percutaneous microwave coagulation therapy is more effective for treating LPLC.

Key words:  Liver neoplasms, Chemoembolization, Percutaneous microwave coagulation therapy, Radioactive ¹²⁵I particle implantation, Efficacy